New Study Shows Link between Hormonal Contraceptives and Depression

According to a Danish study recently published in the Journal of the American Medical Association (JAMA) Psychiatry, there is a link between depression and the use of hormonal contraceptives.

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Even though a lot of research has been done on the use of contraceptives, the study authors highlighted that there was insufficient data on the connection between contraceptives and depression.

Details of the Study

Researchers from the University of Copenhagen studied over a million women in Denmark between the ages of 15 and 34. The study took place over a period of 13 years using data from the National Prescription Register and the Psychiatric Central Research Register in Denmark.

According to an abstract from the JAMA Psychiatry, the women were selected according to the following criteria:

  • If they had no prior depression diagnosis,
  • Having not redeemed prescription for antidepressants,
  • Not having any other major psychiatric diagnosis,
  • Not using cancer, venous thrombosis, or infertility treatment

The researchers tested for depression by checking either for a depression diagnosis at a psychiatric hospital or the use of antidepressants.

Results

NPR reports that only 2 percent of the women in the study group received a depression diagnosis, whereas 13 percent filled prescriptions for antidepressants.

The contraceptive pills that had both estrogen and progestin made the women who used them 23 percent more likely to turn to antidepressants. Those who took pills with only progestin were 34 percent more likely to get antidepressants.

For teen girls taking pills with estrogen and progestin, there was an 80 percent relative risk of depression. The risk went up to 120 percent for progestin-only pills.

In a press release, the researchers said, “Millions of women worldwide use hormonal contraception. Despite the clinical evidence of an influence of hormonal contraception on some women’s mood, associations between the use of hormonal contraception and mood disturbances remain inadequately addressed.”

When it came to other forms of hormonal birth control such as Intrauterine Devices (IUDs) and vaginal rings, prescriptions for antidepressants went up by 40 percent for the former and 60 percent for the latter. For those using hormonal patches, the rate of antidepressant prescriptions went up by up to 100 percent.

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With so many prevailing risks of depression, it is important to ensure that steps are taken to protect the society. Since teenage girls are most vulnerable to this threat, women should take a proactive role in educating not only themselves, but also pay special attention to the women of the future.

Studies such as this one from the Danish researchers help to shed a light on subject matter that is rarely discussed. While their conclusions might be up for debate from some of their peers, this study still presents data that will inform women and help them to protect themselves.

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